Investigating and Correcting Plasma DNA Sequencing Coverage Bias to Enhance Aneuploidy Discovery

Pregnant women carry a mixture of cell-free DNA fragments from self and fetus (non-self) in their circulation. In recent years multiple independent studies have demonstrated the ability to detect fetal trisomies such as trisomy 21, the cause of Down syndrome, by Next-Generation Sequencing of materna...

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Main Authors: Chandrananda, Dineika, Thorne, Natalie P., Ganesamoorthy, Devika, Bruno, Damien L., Benjamini, Yuval, Speed, Terence P., Slater, Howard R., Bahlo, Melanie
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2014
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906086/
https://ncbi.nlm.nih.gov/pubmed/24489824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086993
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