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Summarizing and correcting the GC content bias in high-throughput sequencing
GC content bias describes the dependence between fragment count (read coverage) and GC content found in Illumina sequencing data. This bias can dominate the signal of interest for analyses that focus on measuring fragment abundance within a genome, such as copy number estimation (DNA-seq). The bias...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378858/ https://ncbi.nlm.nih.gov/pubmed/22323520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks001 |
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