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Pre-activation of the genome integrity checkpoint increases DNA damage tolerance
The genome integrity checkpoint is a conserved signaling pathway that is regulated in yeast by the Mec1 (homologous to human ATR) and Rad53 (homologous to human Chk1) kinases. The pathway coordinates a multifaceted response that allows cells to cope with DNA damage and DNA replication stress. The fu...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905891/ https://ncbi.nlm.nih.gov/pubmed/24049076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt820 |
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