Dynamin 2 Potentiates Invasive Migration of Pancreatic Tumor Cells through Stabilization of the Rac1 GEF Vav1

The large GTPase Dynamin 2 (Dyn2) is markedly upregulated in pancreatic cancer, is a potent activator of metastatic migration, and is required for Rac1-mediated formation of lamellipodia. Here we demonstrate an unexpected mechanism of Dyn2 action in these contexts, via direct binding to the Rac1 gua...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Razidlo, Gina L., Wang, Yu, Chen, Jing, Krueger, Eugene W., Billadeau, Daniel D., McNiven, Mark A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905678/
https://ncbi.nlm.nih.gov/pubmed/23537630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.02.010
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker