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The capacity to induce cross-presentation dictates the success of a TLR7 agonist-conjugate vaccine for eliciting cellular immunity

Covalent conjugation of TLR agonists to protein antigens often facilitates the generation of a CD8(+) T cell response. However, mechanisms underlying the efficacy of the conjugate over its unconjugated counterpart have been largely uninvestigated. In this study, we show that conjugation of a TLR7 ag...

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Detalhes bibliográficos
Main Authors: Oh, Jason Z., Kedl, Ross M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905619/
https://ncbi.nlm.nih.gov/pubmed/20844205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001892
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