Dihydroceramide Desaturase Knockdown Impacts Sphingolipids and Apoptosis after Photodamage in Human Head and Neck Squamous Carcinoma Cells

BACKGROUND: Dihydroceramide desaturase 1 (DES) is the enzyme responsible for converting dihydroceramide into ceramide in the de novo sphingolipid biosynthesis pathway. Dihydroceramide can inhibit ceramide channel formation to interfere with apoptosis. We have shown that following ceramide synthase k...

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Autori principali: BREEN, PAUL, JOSEPH, NICHOLAS, THOMPSON, KYLE, KRAVEKA, JACQUELINE M., GUDZ, TATYANA I., LI, LI, RAHMANIYAN, MEHRDAD, BIELAWSKI, JACEK, PIERCE, JASON S., VAN BUREN, ERIC, BHATTI, GAURAV, SEPAROVIC, DUSKA
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905466/
https://ncbi.nlm.nih.gov/pubmed/23267130
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