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Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus

To discover quantitative trait loci for intraocular pressure, a major risk factor for glaucoma and the only modifiable one, we performed a genome-wide association study on a discovery cohort of 2175 individuals from Sydney, Australia. We found a novel association between intraocular pressure and a c...

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Detalhes bibliográficos
Main Authors: Strange, Amy, Bellenguez, Céline, Sim, Xueling, Luben, Robert, Hysi, Pirro G., Ramdas, Wishal D., van Koolwijk, Leonieke M.E., Freeman, Colin, Pirinen, Matti, Su, Zhan, Band, Gavin, Pearson, Richard, Vukcevic, Damjan, Langford, Cordelia, Deloukas, Panos, Hunt, Sarah, Gray, Emma, Dronov, Serge, Potter, Simon C., Tashakkori-Ghanbaria, Avazeh, Edkins, Sarah, Bumpstead, Suzannah J., Blackwell, Jenefer M., Bramon, Elvira, Brown, Matthew A., Casas, Juan P., Corvin, Aiden, Duncanson, Audrey, Jankowski, Janusz A.Z., Markus, Hugh S., Mathew, Christopher G., Palmer, Colin N.A., Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J., Trembath, Richard C., Wood, Nicholas W., Barroso, Ines, Peltonen, Leena, Healey, Paul, McGuffin, Peter, Topouzis, Fotis, Klaver, Caroline C.W., van Duijn, Cornelia M., Mackey, David A., Young, Terri L., Hammond, Christopher J., Khaw, Kay-Tee, Wareham, Nick, Wang, Jie Jin, Wong, Tien Y., Foster, Paul J., Mitchell, Paul, Spencer, Chris C.A., Donnelly, Peter, Viswanathan, Ananth C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904806/
https://ncbi.nlm.nih.gov/pubmed/23836780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt293
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