Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia B

BACKGROUND: Self-complementary adeno-associated virus (scAAV) vectors have become a desirable vector for therapeutic gene transfer due to their ability to produce greater levels of transgene than single-stranded AAV (ssAAV). However, recent reports have suggested that scAAV vectors are more immunoge...

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Bibliografiske detaljer
Main Authors: Rogers, Geoffrey L, Martino, Ashley T, Zolotukhin, Irene, Ertl, Hildegund CJ, Herzog, Roland W
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904690/
https://ncbi.nlm.nih.gov/pubmed/24460861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-12-25
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