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Copper-transporting P-type ATPases use a unique ion-release pathway

Heavy metals in cells are typically regulated by P(IB)-type ATPases such as the copper transporting Cu(+)-ATPases. The first crystal structure of a Cu(+)-ATPase (LpCopA) was trapped in a transition state of dephosphorylation (E2.P(i)) and inferred to be occluded. The structure revealed a P(IB)-speci...

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Detalhes bibliográficos
Main Authors: Andersson, Magnus, Mattle, Daniel, Sitsel, Oleg, Nielsen, Anna Marie, White, Stephen H., Nissen, Poul, Gourdon, Pontus
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904665/
https://ncbi.nlm.nih.gov/pubmed/24317491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2721
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