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X-ray structure of the dopamine transporter in complex with tricyclic antidepressant
Antidepressants targeting Na(+)/Cl(−)-coupled neurotransmitter uptake define a major therapeutic strategy to treat clinical depression and neuropathic pain. However, identifying the molecular interactions that underlie the pharmacological activity of these transport inhibitors and thus the mechanism...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904663/ https://ncbi.nlm.nih.gov/pubmed/24037379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12533 |
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