Prostaglandin D(2) toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites

Prostaglandin D(2) (PGD(2)) is the most abundant prostaglandin in brain but its effect on neuronal cell death is complex and not completely understood. PGD(2) may modulate neuronal cell death via activation of DP receptors or its metabolism to the cyclopentenone prostaglandins (CyPGs) PGJ(2), Δ(12)-...

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Bibliographic Details
Main Authors: Liu, Hao, Li, Wenjin, Rose, Marie E., Pascoe, Jordan L., Miller, Tricia M., Ahmad, Muzamil, Poloyac, Samuel M., Hickey, Robert W., Graham, Steven H.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904641/
https://ncbi.nlm.nih.gov/pubmed/23973622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2013.08.001
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