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Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis
TGF-β is essential for vascular development; however, excess TGF-β signaling promotes thoracic aortic aneurysm and dissection in multiple disorders, including Marfan syndrome. Since the pathology of TGF-β overactivity manifests primarily within the arterial media, it is widely assumed that suppressi...
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| Главные авторы: | , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904608/ https://ncbi.nlm.nih.gov/pubmed/24401272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69942 |
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