mTOR Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice

OBJECTIVE: Elastin deficiency due to heterozygous loss of an ELN allele in Williams syndrome causes obstructive aortopathy characterized by medial thickening and fibrosis and consequent aortic stiffening. Previous work in Eln-null mice with a severe arterial phenotype showed that inhibition of mecha...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Jiao, Yang, Li, Guangxin, Li, Qingle, Ali, Rahmat, Qin, Lingfeng, Li, Wei, Qyang, Yibing, Greif, Daniel M., Geirsson, Arnar, Humphrey, Jay D., Tellides, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574180/
https://ncbi.nlm.nih.gov/pubmed/28751568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309653
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados