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mTOR Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice
OBJECTIVE: Elastin deficiency due to heterozygous loss of an ELN allele in Williams syndrome causes obstructive aortopathy characterized by medial thickening and fibrosis and consequent aortic stiffening. Previous work in Eln-null mice with a severe arterial phenotype showed that inhibition of mecha...
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| Udgivet i: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5574180/ https://ncbi.nlm.nih.gov/pubmed/28751568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309653 |
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