Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

TGF-β is essential for vascular development; however, excess TGF-β signaling promotes thoracic aortic aneurysm and dissection in multiple disorders, including Marfan syndrome. Since the pathology of TGF-β overactivity manifests primarily within the arterial media, it is widely assumed that suppressi...

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Detalhes bibliográficos
Main Authors: Li, Wei, Li, Qingle, Jiao, Yang, Qin, Lingfeng, Ali, Rahmat, Zhou, Jing, Ferruzzi, Jacopo, Kim, Richard W., Geirsson, Arnar, Dietz, Harry C., Offermanns, Stefan, Humphrey, Jay D., Tellides, George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904608/
https://ncbi.nlm.nih.gov/pubmed/24401272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69942
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