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mCSM: predicting the effects of mutations in proteins using graph-based signatures

Motivation: Mutations play fundamental roles in evolution by introducing diversity into genomes. Missense mutations in structural genes may become either selectively advantageous or disadvantageous to the organism by affecting protein stability and/or interfering with interactions between partners....

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Detalhes bibliográficos
Main Authors: Pires, Douglas E. V., Ascher, David B., Blundell, Tom L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904523/
https://ncbi.nlm.nih.gov/pubmed/24281696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btt691
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