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RML prions act through Mahogunin and Attractin-independent pathways

While the conversion of the normal form of prion protein to a conformationally distinct pathogenic form is recognized to be the primary cause of prion disease, it is not clear how this leads to spongiform change, neuronal dysfunction and death. Mahogunin ring finger-1 (Mgrn1) and Attractin (Atrn) nu...

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Autores principales: Gunn, Teresa M, Carlson, George A
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904309/
https://ncbi.nlm.nih.gov/pubmed/23787699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.25054
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