Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation

Background and Purpose: Chlormethiazole (CMZ), a clinical sedative/anxiolytic agent, did not reach clinical efficacy in stroke trials despite neuroprotection demonstrated in numerous animal models. Using CMZ as a lead compound, neuroprotective methiazole (MZ) analogues were developed, and neuroprote...

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Bibliographische Detailangaben
Hauptverfasser: VandeVrede, Lawren, Tavassoli, Ehsan, Luo, Jia, Qin, Zhihui, Yue, Lan, Pepperberg, David R, Thatcher, Gregory R
Format: Artigo
Sprache:Inglês
Veröffentlicht: The British Pharmacological Sociey 2014
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904259/
https://ncbi.nlm.nih.gov/pubmed/24116891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12454
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