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Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure

Type III secretion (TTS) is an essential virulence factor for Shigella flexneri, the causative agent of shigellosis. The Shigella TTS apparatus (TTSA) is an elegant nano-machine that is composed of a basal body, an external needle to deliver effectors into human cells, and a needle tip complex that...

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Main Authors: Barta, Michael L., Guragain, Manita, Adam, Philip, Dickenson, Nicholas E., Patil, Mrinalini, Geisbrecht, Brian V., Picking, Wendy L., Picking, William D.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903301/
https://ncbi.nlm.nih.gov/pubmed/22423359
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