Conformational Changes in IpaD from Shigella flexneri Upon Binding Bile Salts Provide Insight into the Second Step of Type III Secretion

Shigella flexneri uses its type III secretion apparatus (TTSA) to inject host-altering proteins into targeted eukaryotic cells. The TTSA is composed of a basal body and an exposed needle with invasion plasmid antigen D (IpaD) forming a tip complex that controls secretion. The bile salt deoxycholate...

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Hlavní autoři: Dickenson, Nicholas E., Zhang, Lingling, Epler, Chelsea R., Adam, Philip R., Picking, Wendy L., Picking, William D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130115/
https://ncbi.nlm.nih.gov/pubmed/21126091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101365f
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