Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival

Bcl-2 interacts with the inositol 1,4,5-trisphosphate receptor (InsP(3)R) and thus prevents InsP(3)-induced Ca(2+) elevation that induces apoptosis. Here we report that Bcl-2 binds dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), a protein kinase A (PKA)-activated and calcineurin (C...

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Bibliographische Detailangaben
Hauptverfasser: Chang, Ming-Jin, Zhong, Fei, Lavik, Andrew R., Parys, Jan B., Berridge, Michael J., Distelhorst, Clark W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903247/
https://ncbi.nlm.nih.gov/pubmed/24395794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323098111
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