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Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival
Bcl-2 interacts with the inositol 1,4,5-trisphosphate receptor (InsP(3)R) and thus prevents InsP(3)-induced Ca(2+) elevation that induces apoptosis. Here we report that Bcl-2 binds dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), a protein kinase A (PKA)-activated and calcineurin (C...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3903247/ https://ncbi.nlm.nih.gov/pubmed/24395794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323098111 |
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