Quantitative high-throughput analysis of transcription factor binding specificities

We present a general high-throughput approach to accurately quantify DNA–protein interactions, which can facilitate the identification of functional genetic polymorphisms. The method tested here on two structurally distinct transcription factors (TFs), NF-κB and OCT-1, comprises three steps: (i) opt...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Linnell, Jane, Mott, Richard, Field, Simon, Kwiatkowski, Dominic P., Ragoussis, Jiannis, Udalova, Irina A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2004
Assuntos:	NAR Methods Online
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390317/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14990752/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gnh042
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