Quantitative high-throughput analysis of transcription factor binding specificities

We present a general high-throughput approach to accurately quantify DNA–protein interactions, which can facilitate the identification of functional genetic polymorphisms. The method tested here on two structurally distinct transcription factors (TFs), NF-κB and OCT-1, comprises three steps: (i) opt...

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Detalles Bibliográficos
Autores principales: Linnell, Jane, Mott, Richard, Field, Simon, Kwiatkowski, Dominic P., Ragoussis, Jiannis, Udalova, Irina A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2004
Materias:
NAR Methods Online
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC390317/
https://ncbi.nlm.nih.gov/pubmed/14990752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnh042
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