Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties

Human APOBEC3A (A3A) is a single-domain cytidine deaminase that converts deoxycytidine residues to deoxyuridine in single-stranded DNA (ssDNA). It inhibits a wide range of viruses and endogenous retroelements such as LINE-1, but it can also edit genomic DNA, which may play a role in carcinogenesis....

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Hoofdauteurs: Mitra, Mithun, Hercík, Kamil, Byeon, In-Ja L., Ahn, Jinwoo, Hill, Shawn, Hinchee-Rodriguez, Kathyrn, Singer, Dustin, Byeon, Chang-Hyeock, Charlton, Lisa M., Nam, Gabriel, Heidecker, Gisela, Gronenborn, Angela M., Levin, Judith G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2014
Onderwerpen:
Molecular Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902935/
https://ncbi.nlm.nih.gov/pubmed/24163103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt945
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