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NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity
Human APOBEC3A (A3A) is a single-stranded DNA (ssDNA) cytidine deaminase that restricts viral pathogens and endogenous retrotransposons and plays a role in the innate immune response. Furthermore, its potential to act as a genomic DNA mutator has implications for a role in carcinogenesis. A deeper u...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674325/ https://ncbi.nlm.nih.gov/pubmed/23695684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2883 |
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