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Quantitative influence of macromolecular crowding on gene regulation kinetics
We introduce macromolecular crowding quantitatively into the model for kinetics of gene regulation in Escherichia coli. We analyse and compute the specific-site searching time for 180 known transcription factors (TFs) regulating 1300 operons. The time is between 160 s (e.g. for SoxS M(w) = 12.91 kDa...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3902910/ https://ncbi.nlm.nih.gov/pubmed/24121687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt907 |
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