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Macromolecular Crowding Regulates the Gene Expression Profile by Limiting Diffusion

We seek to elucidate the role of macromolecular crowding in transcription and translation. It is well known that stochasticity in gene expression can lead to differential gene expression and heterogeneity in a cell population. Recent experimental observations by Tan et al. have improved our understa...

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Bibliografische gegevens
Gepubliceerd in:PLoS Comput Biol
Hoofdauteurs: Golkaram, Mahdi, Hellander, Stefan, Drawert, Brian, Petzold, Linda R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125560/
https://ncbi.nlm.nih.gov/pubmed/27893768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005122
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