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Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria

Self-assembly of phenylalanine is linked to amyloid formation toxicity in phenylketonuria disease. We are demonstrating that L-phenylalanine self-assembles to amyloid fibrils at varying experimental conditions and transforms to a gel state at saturated concentration. Biophysical methods including nu...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Singh, Virender, Rai, Ratan Kumar, Arora, Ashish, Sinha, Neeraj, Thakur, Ashwani Kumar
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902384/
https://ncbi.nlm.nih.gov/pubmed/24464217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03875
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