A Purine Nucleotide Biosynthesis Enzyme Guanosine Monophosphate Reductase is a Suppressor of Melanoma Invasion

Melanoma is one of the most aggressive types of human cancers, and the mechanisms underlying melanoma invasive phenotype are not completely understood. Here, we report that expression of guanosine monophosphate reductase (GMPR), an enzyme involved in de novo biosynthesis of purine nucleotides, was d...

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Huvudupphovsmän: Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Bshara, Wiam, Mannava, Sudha, Ackroyd, Jeff, Bagati, Archis, Omilian, Angela R., Im, Michael, Fedtsova, Natalia, Miecznikowski, Jeffrey C., Moparthy, Kalyana C., Zucker, Shoshanna N., Zhu, Qianqian, Kozlova, Nadezhda I., Berman, Albert E., Hoek, Keith S., Gudkov, Andrei V., Shewach, Donna S., Morrison, Carl D., Nikiforov, Mikhail A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902135/
https://ncbi.nlm.nih.gov/pubmed/24139804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.09.015
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