PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells

BACKGROUND: Combination therapy is key to improving cancer treatment efficacy. Phorbol 12-myristate 13-acetate (PMA), a well-known PKC activator, increases the cytotoxicity of several anticancer drugs. Apicularen A induces cytotoxicity in tumor cells through disrupting microtubule networks by tubuli...

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Hlavní autoři: Seo, Kang-Sik, Kim, Jong-Seok, Park, Ji-Hoon, Song, Kyoung-Sub, Yun, Eun-Jin, Park, Jong-Il, Kweon, Gi Ryang, Yoon, Wan-Hee, Lim, Kyu, Hwang, Byung-Doo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901760/
https://ncbi.nlm.nih.gov/pubmed/24447339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-36
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