AMPK Inhibition Blocks ROS-NFκB Signaling and Attenuates Endotoxemia-Induced Liver Injury

BACKGROUND: AMP-activated protein kinase (AMPK) is an important enzyme in regulation of cellular energy homeostasis. We have previously shown that AMPK activation by 5-aminoimidazole-4-carboxamide (AICAR) results in suppression of immune responses, indicating the pivotal role of AMPK in immune regul...

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Bibliographische Detailangaben
Hauptverfasser: Guo, Yuan, Zhang, Yi, Hong, Kai, Luo, Fengyan, Gu, Qiuping, Lu, Nonghua, Bai, Aiping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901729/
https://ncbi.nlm.nih.gov/pubmed/24475189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086881
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