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Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development

Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The pr...

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Библиографические подробности
Главный автор: Gileadi, Opher
Формат: Artigo
Язык:Inglês
Опубликовано: Portland Press Ltd. 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901396/
https://ncbi.nlm.nih.gov/pubmed/24450636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20130228
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