Synthetic embryonic lethality upon deletion of the ER cochaperone p58(IPK) and the ER stress sensor ATF6α

The unfolded protein response (UPR) is activated as a consequence of alterations to ER homeostasis. It upregulates a group of ER chaperones and cochaperones, as well as other genes that improve protein processing within the secretory pathway. The UPR effector ATF6α augments—but is not essential for—...

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Bibliographic Details
Main Authors: Gomez, Javier A., Tyra, Heather M., McCabe, Diane DeZwaan, Olivier, Alicia K., Rutkowski, D. Thomas
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901050/
https://ncbi.nlm.nih.gov/pubmed/24275136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.11.060
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