miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hepatocellular Carcinoma

In contrast to normal differentiated cells that depend on mitochondrial oxidative phosphorylation for energy production, cancer cells have evolved to utilize aerobic glycolysis (Warburg’s effect), with benefit of providing intermediates for biomass production. MicroRNA-122 (miR-122) is highly expres...

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Bibliographic Details
Main Authors: Liu, Angela M., Xu, Zhi, Shek, Felix H., Wong, Kwong-Fai, Lee, Nikki P., Poon, Ronnie T., Chen, Jinfei, Luk, John M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900676/
https://ncbi.nlm.nih.gov/pubmed/24466275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086872
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