Clostridium perfringens Phospholipase C Induced ROS Production and Cytotoxicity Require PKC, MEK1 and NFκB Activation

Clostridium perfringens phospholipase C (CpPLC), also called α-toxin, is the most toxic extracellular enzyme produced by this bacteria and is essential for virulence in gas gangrene. At lytic concentrations, CpPLC causes membrane disruption, whereas at sublytic concentrations this toxin causes oxida...

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Hlavní autoři: Monturiol-Gross, Laura, Flores-Díaz, Marietta, Pineda-Padilla, Maria Jose, Castro-Castro, Ana Cristina, Alape-Giron, Alberto
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900566/
https://ncbi.nlm.nih.gov/pubmed/24466113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086475
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