Clostridium perfringens Phospholipase C Induced ROS Production and Cytotoxicity Require PKC, MEK1 and NFκB Activation

Clostridium perfringens phospholipase C (CpPLC), also called α-toxin, is the most toxic extracellular enzyme produced by this bacteria and is essential for virulence in gas gangrene. At lytic concentrations, CpPLC causes membrane disruption, whereas at sublytic concentrations this toxin causes oxida...

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Bibliographic Details
Main Authors: Monturiol-Gross, Laura, Flores-Díaz, Marietta, Pineda-Padilla, Maria Jose, Castro-Castro, Ana Cristina, Alape-Giron, Alberto
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900566/
https://ncbi.nlm.nih.gov/pubmed/24466113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086475
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