Reduced Renal α-Klotho Expression in CKD Patients and Its Effect on Renal Phosphate Handling and Vitamin D Metabolism

Renal α-Klotho (α-KL) plays a fundamental role as a co-receptor for fibroblast growth factor 23 (FGF23), a phosphaturic hormone and regulator of 1,25(OH)(2) vitamin D(3) (1,25VitD(3)). Disruption of FGF23-α-KL signaling is thought to be an early hallmark of chronic kidney disease (CKD) involving red...

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Autori principali: Sakan, Hirokazu, Nakatani, Kimihiko, Asai, Osamu, Imura, Akihiro, Tanaka, Tomohiro, Yoshimoto, Shuhei, Iwamoto, Noriyuki, Kurumatani, Norio, Iwano, Masayuki, Nabeshima, Yo-ichi, Konishi, Noboru, Saito, Yoshihiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900516/
https://ncbi.nlm.nih.gov/pubmed/24466013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086301
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