Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects

BACKGROUND: α-Klotho (αKl) regulates mineral metabolism such as calcium ion (Ca(2+)) and inorganic phosphate (Pi) in circulation. Defects in mice result in clinical features resembling disorders found in human aging. Although the importance of transmembrane-type αKl has been demonstrated, less is kn...

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Main Authors: Yamazaki, Yuji, Imura, Akihiro, Urakawa, Itaru, Shimada, Takashi, Murakami, Junko, Aono, Yukiko, Hasegawa, Hisashi, Yamashita, Takeyoshi, Nakatani, Kimihiko, Saito, Yoshihiko, Okamoto, Nozomi, Kurumatani, Norio, Namba, Noriyuki, Kitaoka, Taichi, Ozono, Keiichi, Sakai, Tomoyuki, Hataya, Hiroshi, Ichikawa, Shoji, Imel, Erik A., Econs, Michael J., Nabeshima, Yo-ichi
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130489/
https://ncbi.nlm.nih.gov/pubmed/20599764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.06.110
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