A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast

Unbiased lipidomic approaches have identified impairments in glycerophosphocholine second messenger metabolism in patients with Alzheimer's disease. Specifically, we have shown that amyloid-β42 signals the intraneuronal accumulation of PC(O-16:0/2:0) which is associated with neurotoxicity. Simi...

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Xehetasun bibliografikoak
Egile Nagusiak: Kennedy, Michael A., Gable, Kenneth, Niewola-Staszkowska, Karolina, Abreu, Susana, Johnston, Anne, Harris, Linda J., Reggiori, Fulvio, Loewith, Robbie, Dunn, Teresa, Bennett, Steffany A. L., Baetz, Kristin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900389/
https://ncbi.nlm.nih.gov/pubmed/24465216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004010
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