Assessment of Beating Parameters in Human Induced Pluripotent Stem Cells Enables Quantitative In Vitro Screening for Cardiotoxicity

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes show promise for screening during early drug development. Here, we tested a hypothesis that in vitro assessment of multiple cardiomyocyte physiological parameters enables predictive and mechanistically-interpretable evaluation of card...

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Bibliografiska uppgifter
Huvudupphovsmän: Sirenko, Oksana, Cromwell, Evan F., Crittenden, Carole, Wignall, Jessica A., Wright, Fred A., Rusyn, Ivan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900303/
https://ncbi.nlm.nih.gov/pubmed/24095675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.09.017
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