Serine-204 in the Linker Region of Smad3 Mediates the Collagen-I Response to TGF-β in a Cell Phenotype-Specific Manner

Regulation of TGF-β1/Smad3 signaling in fibrogenesis is complex. Previous work by our lab suggests that ERK MAP kinase phosphorylates the linker region (LR) of Smad3 to enhance TGF-β-induced collagen-I accumulation. However the roles of the individual Smad3LR phosphorylation sites (T179, S204, S208...

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Bibliographic Details
Main Authors:	Browne, James A., Liu, Xiaoying, Schnaper, H. William, Hayashida, Tomoko
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3900285/ https://ncbi.nlm.nih.gov/pubmed/24080014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2013.07.013
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Serine-204 in the Linker Region of Smad3 Mediates the Collagen-I Response to TGF-β in a Cell Phenotype-Specific Manner

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