Autocrine VEGF Signaling Promotes Proliferation of Neoplastic Barrett’s Epithelial Cells Through a PLC-Dependent Pathway

BACKGROUND & AIMS: Tumor cells express vascular endothelial growth factor (VEGF), which induces angiogenesis. VEGF also activates VEGF receptors (VEGFRs) on or within tumor cells to promote their proliferation in an autocrine fashion. We studied the mechanisms of autocrine VEGF signaling in Barr...

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Detalhes bibliográficos
Main Authors: Zhang, Qiuyang, Yu, Chunhua, Peng, Sui, Xu, Hao, Wright, Ellen, Zhang, Xi, Huo, Xiaofang, Cheng, Edaire, Pham, Thai H., Asanuma, Kiyotaka, Hatanpaa, Kimmo J., Rezai, Davood, Wang, David H., Sarode, Venetia, Melton, Shelby, Genta, Robert M., Spechler, Stuart J., Souza, Rhonda F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899829/
https://ncbi.nlm.nih.gov/pubmed/24120473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.10.011
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