Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma

Ewing sarcoma provides an important model for transcription-factor mediated oncogenic transformation because of its reliance on the ETS-type fusion oncoprotein EWS/FLI. EWS/FLI functions as a transcriptional activator and transcriptional activation is required for its oncogenic activity. Here we dem...

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Hauptverfasser: Sankar, Savita, Bell, Russell, Stephens, Bret, Zhuo, Rupeng, Sharma, Sunil, Bearss, David J., Lessnick, Stephen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899696/
https://ncbi.nlm.nih.gov/pubmed/23178492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.525
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