EWS/FLI Mediates Transcriptional Repression via NKX2.2 during Oncogenic Transformation in Ewing's Sarcoma

EWS/FLI is a master regulator of Ewing's sarcoma formation. Gene expression studies in A673 Ewing's sarcoma cells have demonstrated that EWS/FLI downregulates more genes than it upregulates, suggesting that EWS/FLI, and/or its targets, function as transcriptional repressors. One critical E...

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Detaylı Bibliyografya
Asıl Yazarlar: Owen, Leah A., Kowalewski, Ashley A., Lessnick, Stephen L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2008
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291578/
https://ncbi.nlm.nih.gov/pubmed/18414662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001965
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