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Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma
Ewing sarcoma provides an important model for transcription-factor mediated oncogenic transformation because of its reliance on the ETS-type fusion oncoprotein EWS/FLI. EWS/FLI functions as a transcriptional activator and transcriptional activation is required for its oncogenic activity. Here we dem...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3899696/ https://ncbi.nlm.nih.gov/pubmed/23178492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.525 |
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