Pax6 Exerts Regional Control of Cortical Progenitor Proliferation via Direct Repression of Cdk6 and Hypophosphorylation of pRb

The mechanisms by which early spatiotemporal expression patterns of transcription factors such as Pax6 regulate cortical progenitors in a region-specific manner are poorly understood. Pax6 is expressed in a gradient across the developing cortex and is essential for normal corticogenesis. We found th...

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Autori principali: Mi, Da, Carr, Catherine B., Georgala, Petrina A., Huang, Yu-Ting, Manuel, Martine N., Jeanes, Emily, Niisato, Emi, Sansom, Stephen N., Livesey, Frederick J., Theil, Thomas, Hasenpusch-Theil, Kerstin, Simpson, T. Ian, Mason, John O., Price, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898967/
https://ncbi.nlm.nih.gov/pubmed/23622063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.02.012
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