Co-occurrence of Risk Alleles in or Near Genes Modulating Insulin Secretion Predisposes Obese Youth to Prediabetes

OBJECTIVE: Paralleling the rise of pediatric obesity, the prevalence of impaired glucose tolerance (IGT) and type 2 diabetes (T2D) is increasing among youth. In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP...

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Main Authors: Giannini, Cosimo, Dalla Man, Chiara, Groop, Leif, Cobelli, Claudio, Zhao, Hongyu, Shaw, Melissa M., Duran, Elvira, Pierpont, Bridget, Bale, Allen E., Caprio, Sonia, Santoro, Nicola
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2014
Teme:
Pathophysiology/Complications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898754/
https://ncbi.nlm.nih.gov/pubmed/24062323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc13-1458
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