Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression()

Mutations of the PTEN-induced kinase 1 (PINK1) gene are a cause of autosomal recessive Parkinson's disease (PD). This gene encodes a mitochondrial serine/threonine kinase, which is partly localized to mitochondria, and has been shown to play a role in protecting neuronal cells from oxidative st...

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Autori principali: Gómez-Sánchez, Rubén, Gegg, Matthew E., Bravo-San Pedro, José M., Niso-Santano, Mireia, Alvarez-Erviti, Lydia, Pizarro-Estrella, Elisa, Gutiérrez-Martín, Yolanda, Alvarez-Barrientos, Alberto, Fuentes, José M., González-Polo, Rosa Ana, Schapira, Anthony H.V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Academic Press 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898697/
https://ncbi.nlm.nih.gov/pubmed/24184327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.10.021
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