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Crystallographic Fragment Based Drug Discovery: Use of a Brominated Fragment Library Targeting HIV Protease

A library of 68 brominated fragments was screened against a new crystal form of inhibited HIV-1 protease in order to probe surface sites in soaking experiments. Often fragments are weak binders with partial occupancy, resulting in weak, difficult-to-fit electron density. The use of a brominated frag...

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Autores principales: Tiefenbrunn, Theresa, Forli, Stefano, Happer, Meaghan, Gonzalez, Ana, Tsai, Yingssu, Soltis, Michael, Elder, John H., Olson, Arthur J., Stout, C. David
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898673/
https://ncbi.nlm.nih.gov/pubmed/23998903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12227
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