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Effects of prostaglandin E(2) on p53 mRNA transcription and p53 mutagenesis during T-cell-independent human B-cell clonal expansion
Within T-cell-dependent germinal centers, p53 gene transcription is repressed by Bcl-6 and is thus less vulnerable to mutation. Malignant lymphomas within inflamed extranodal sites exhibit a relatively high incidence of p53 mutations. The latter might originate from normal B-cell clones manifesting...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Federation of American Societies for Experimental Biology
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3898655/ https://ncbi.nlm.nih.gov/pubmed/24145719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-237792 |
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