Effects of prostaglandin E(2) on p53 mRNA transcription and p53 mutagenesis during T-cell-independent human B-cell clonal expansion

Within T-cell-dependent germinal centers, p53 gene transcription is repressed by Bcl-6 and is thus less vulnerable to mutation. Malignant lymphomas within inflamed extranodal sites exhibit a relatively high incidence of p53 mutations. The latter might originate from normal B-cell clones manifesting...

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Detaylı Bibliyografya
Asıl Yazarlar: Haque, Shabirul, Yan, Xiao Jie, Rosen, Lisa, McCormick, Steven, Chiorazzi, Nicholas, Mongini, Patricia K. A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Federation of American Societies for Experimental Biology 2014
Konular:
Research Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898655/
https://ncbi.nlm.nih.gov/pubmed/24145719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-237792
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